Dialysis High Flux

Dialysis High FluxSeveral other aspects of modern dialysis, including the use of bicarbonate dialysate, are an essential part of high flux dialysis. However, they are now typically part of conventional dialysis as well. Bicarbonate is now routinely used as the dialysate buffer because the acetate that was used previously caused dilatation of blood vessels and resulted in low blood pressure. Another characteristic of high flux dialysis is that the membranes used are more biocompatible, and therefore are less likely to stimulate the bodys immune system. This minimizes the allergic symptoms as well as the changes in white blood cell counts that were previously caused by less biocompatible membranes.The major possible disadvantage of high flux dialysis regards pyrogen reactions. These reactions, characterized by high temperatures in patients during dialysis treatments, are caused by small pieces of dead bacteria that can be found in the dialysate. Although these reactions are not dangerous, they are uncomfortable for patients, and typically require short hospitalizations for observation. Some nephrologists feel that because high flux dialyzers have larger pores, the bacterial particles can pass more easily into the patients bloodstream, and that patients on high flux dialysis have more frequent pyrogen reactions. This observation remains to be confirmed.

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