InterlesionalHe showed significant improvement by injecting the drug into the wound margin after surgical excision or dermabrasion of the keloid. In 1966 Griffith3 and Ketchum and associates reported that significant  relief of symptoms and improvement of the appearance of keloids resulted after the intralesional injection of triamcinolone acetonide.However, the injection of the solution into these scars has presented a serious problem. Keloids and hypertrophic scars are extremely firm and dense, and injection of any solution into this type of tissue is difficult and painful. A prior injection with a local anesthetic around the scar is often necessary to prevent the severe discomfort which results from distention of the scar by the steroid. A series of injections over a period of several weeks and months are frequently necessary, making this method of treatment a rather unpleasant and painful experience to the patient.




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